Amyotrophic lateral sclerosis (ALS) is adevastating adult-onset disease characterized by gradual degeneration of upperand lower motor neurons (MN) which leads to progressive muscle weakness andparalysis. Non-cell autonomous mechanisms are nowadays considered to play acrucial role in its onset and progression. Thus, the skeletal muscle ishypothesized to actively contribute to ALS
Plan de Valorización y Transferencia
Institutuak, Berrikuntzan Laguntzeko Unitatearen bidez, emaitzak balioztatzen eta transferitzen laguntzearen alde egiten du. Apustu hori ezagutarazteko, Institutuaren Balorizazio eta Transferentzia Plan berria aurkeztu da. Plan horren helburua da transferentzian dauden emaitzak eta aktiboak bultzatzea, baina baita ikertzaileak gaitzea ere, askotan hain ezaguna ez den esparru horren inguruan zenbait erabaki har ditzaten.
From benign liver disease to cancer: a matter of life and death
Chronic liver diseases represent an escalating global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as a key driver of hepatocarcinogenesis. This seminar highlights the critical role of RIPK3, a central effector of necroptosis—a regulated, pro-inflammatory form of cell death—in liver disease progression. In MASLD, RIPK3 promotes hepatic
Generation and validation of novel families of multi-target small molecules against glioblastoma
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults and is characterized by its high heterogeneity, which makes current treatments have limited efficacy. In this context, both indole-based and multitargeted compounds have emerged as potential strategies for the development of new drugs for the treatment of
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by the death of upper and lower motor neurons (MN) and severe muscle atrophy. In recent years, it has been shown that the degeneration MNs can also be caused or exacerbated by other neighbouring cells such as glial cells or
Workshop on Centenarians: Models of healthy aging
Pertsona guztiak ez dira berdin adintzen, eta populazio-talde batzuek adintzeari osasuntsuari buruzko gaokoak eman ditzakete. Ildo horretan, mendeurrenak oso bizitza-luzera handia duen populazio-taldea dira, eta, nazioarteko zenbait ikerketak erakutsi dutenez, haien muturreko bizitza-luzera jarduera kognitiboari hobeto eustearekin batera dator, komorbilitate gutxiagorekin eta bizi-kalitate hobearekin batera. Espainiako Mendeurreneko Ikerketa Taldearen V.
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