Nerve trauma often results in severe sensory and motor function loss due to axonal damage and demyelination. Current strategies aim to prevent neuromas formation and support guided nerve regeneration. Hydrogels, owing to their biomimetic properties, offer a promising platform for such applications. The thesis introduces three novel hydrogel types: PVA/CNT

Neoadjuvant endocrine therapy (NET) in oestrogen receptor-positive (ER+) / HER2-negative (HER2-) breast cancer (BC) allows real-time evaluation of treatment sensitivity and offers the opportunity of personalised BC therapy. However, the lack of reproducible biomarkers to assess response and long-term prognosis after NET is a significant barrier to increase its indications.

Neurological diseases and mental disorders pose a major challenge due to their high prevalence and progressive neuronal degeneration, which often disrupts neurotransmitter release. Among the most critical neurotransmitters are glutamate and dopamine, both deeply involved in key neurophysiological processes and strongly associated with disorders like Parkinson’s, Alzheimer’s, and epilepsy. To

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative diseasecharacterized by the progressive loss of upper and lower motor neurons (MNs),leading to muscle weakness, atrophy, and eventually paralysis andrespiratory failure. A central pathological feature of ALS is TDP-43proteinopathy, which involves both the loss of nuclear function and theaggregation of TDP-43 in the cytoplasm. TDP-43