El Reglamento del Espacio Europeo de Datos ha sido recientemente aprobado. En su virtud, muchas de las prácticas relativas al tratamiento de datos para fines de investigación o innovación cambiarán radicalmente dentro de cuatro o seis años. El nuevo sistema permitirá superar muchas de las limitaciones del modelo actual, pero

SOX2 drives fetal reprogramming and reversible dormancy in colorectal cancer Cellular plasticity plays critical roles in tissue regeneration, tumour progression and therapeutic resistance. However, the mechanism underlying this cell state transition remains elusive. Here, we show that the transcription factor SOX2 induces fetal reprogramming and reversible dormancy in colorectal cancer (CRC). SOX2 expression correlates with fetal reprogramming and poor prognosis

Triple negative breast cancers (TNBC) exhibit inter- and intra-tumour heterogeneity, which is reflected in diverse drug responses and interplays with tumour evolution. Here, we develop a preclinical experimental and analytical framework using treatment-naive TNBC patient-derived tumour xenografts (PDTX) to test their predictive value in personalised cancer treatment approaches. We observed that