DNA is the major target of radiation therapy of malignant tumors. Amongst ionizing-radiation (IR)-induced DNA damage, DNA double-strand breaks (DSBs) are one of the most severe DNA lesions a cell can incur, leading to cell death. Despite the day-by-day improvements of cancer diagnosis and treatments, tumor-neighboring healthy tissues are still

Recent human studies strongly support the view that loss of TDP-43 splicing repression underlies the pathogenesis of ALS-FTD, a disorder spectrum currently without disease modifying therapy. To address this unmet need, we employ an AAV gene therapy approach to complement the loss of TDP-43 by delivering a novel splicing repressor

In 2024, there will likely be 20 million new cancer cases (approximately 10 million cancer deaths) worldwide. While anti-cancer drugs like doxorubicin (DOX) are beneficial, they often induce off-target effects such as skeletal muscle fatigue and weakness. These myopathies affect up to 80% of cancer patients, persisting long after treatment