The gut-liver axis serves as a crucial pathway through which gut microbes communicate and exert influence over the host’s physiology. Microbial-derived metabolites are key messengers, as they lie at the interface between the microbes and their host. Deciphering specific microbial functions and their metabolic products is essential for advancing targeted

Transcriptome editing has opened a variety of possibilities for new therapeutic strategies, including the modulation of mRNA splicing using antisense oligonucleotides (ASOs), a treatment already approved for spinal muscular atrophy (SMA). However, the use of ASOs presents some disadvantages, and is important to explore alternative strategies, such as engineered RNA-binding

GRN emerges as a pivotal regulator in response to metabolic stress. Current research indicates that GRN plays a crucial role in lysosomal biogenesis and function, which are essential for the cellular degradation pathways that manage waste. Our observations demonstrate that GRN is upregulated and localized to stress granules following metabolic

Multiple Sclerosis (MS) is a chronic, inflammatory, neurodegenerative and immune-mediated disease that primarily affects young adults, leading to disability and imposing a significant socioeconomic burden. Although its exact cause remains unclear, both genetic and environmental factors are involved. Among the environmental factors, the microbiome has gained attention for its association