Gut-liver axis: what are microbes doing?
The gut-liver axis serves as a crucial pathway through which gut microbes communicate and exert influence over the host’s physiology. Microbial-derived metabolites are key messengers, as they lie at the interface between the microbes and their host. Deciphering specific microbial functions and their metabolic products is essential for advancing targeted
Transcriptome editing has opened a variety of possibilities for new therapeutic strategies, including the modulation of mRNA splicing using antisense oligonucleotides (ASOs), a treatment already approved for spinal muscular atrophy (SMA). However, the use of ASOs presents some disadvantages, and is important to explore alternative strategies, such as engineered RNA-binding
GRN emerges as a pivotal regulator in response to metabolic stress. Current research indicates that GRN plays a crucial role in lysosomal biogenesis and function, which are essential for the cellular degradation pathways that manage waste. Our observations demonstrate that GRN is upregulated and localized to stress granules following metabolic
HISTORIA – ZIENTZIA Zikloa: Emakumeak: sexua eta ugalketa. kontatu gabeko istorioa
Irungo Oiasso Museoak eta Biogipuzkoa Osasun Ikerketa Institutuak abian jarri dute “Historia – Zientzia” urteko zikloaren bigarren edizioa. Ziklo honen helburua da osasun-ikerketak eta ezagutza zientifikoak historian zehar gizartearen aurrerabidean izan duten eta izaten jarraitzen duten eragina zabaltzea. Horretarako, elkarrizketa-formatu batean, bi erakundeek partekatzen eta osatzen dituzten gaiak jorratuko dituzte:
Multiple Sclerosis (MS) is a chronic, inflammatory, neurodegenerative and immune-mediated disease that primarily affects young adults, leading to disability and imposing a significant socioeconomic burden. Although its exact cause remains unclear, both genetic and environmental factors are involved. Among the environmental factors, the microbiome has gained attention for its association
Endoplasmic Reticulum Regulation of Mitochondrial DNA Replication
Mitochondrial function is reliant on interactions with other cell compartments, particularly the endoplasmic reticulum, via endoplasmic reticulum-mitochondrial contact sites (ERMCS). This thesis aims to elucidate how the ER influences mitochondrial DNA (mtDNA) replication, an essential process for cellular energy production and survival. It reveals that mtDNA replication is proportional to
Pint of science 2023, ikertzaileak eta ikusleak tabernetan elkartzea proposatzen duen zientzia-dibulgazio ekimena maiatzaren 22, 23 eta 24an iritsiko da Donostialdeko, tabernak zientzia eta esperientziaz betetzeko asmoz.
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Introducción a la nueva plataforma de proteómica Somascan de Somalogic capaz de detectar de muestras de biopsia líquida entre otras más de 7,000 proteínas, siendo la referencia en el emergente sector de las Ómicas y Medicina de Precisión con aplicaciones que van desde el descubrimiento de biomarcadores, descripción de patologías, correlación con datos genómicos hasta su uso en ensayos clínicos, test de rutina en medicina preventiva o diagnóstico.
En la presentación se dará a conocer la tecnología base de los Aptámeros, la plataforma de inteligencia artificial para el procesamiento de datos, así como ejemplos en distintas áreas de la investigación desde inmuno-oncología, enfermedades metabólicas/cardiovasculares, neurociencias, infecciosas, autoinmunes, hasta las últimas novedades en los campos de Aging.
Asimismo, se presentarán iniciativas en el campo de estudios con biobancos y centros de investigación en proyectos de Population Proteomics.
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