In this presentation, results of a collaborative project between Dr. Kristina W. Whitworth at Baylor College of Medicine in Houston, Texas with INMA investigators will be described.  Briefly, the study goals are to evaluate the impacts of pre- and post-natal fine particulate matter (PM2.5) exposure on children’s cognitive and motor

Tumor cell invasion of lymph nodes facilitates breast cancer progression. The adverse impact of lymph node metastasis necessitates biomarker identification to predict outcomes and guide treatment. We established the Notch ligand, JAG1, as a driver of lymph node metastasis. Tumor microarray analysis of synchronous breast tumor and lymph node samples

Increasing evidence for a direct contribution of astrocytes as well as different apolipoprotein (APOE) variants to Alzheimer’s disease (AD) main pathological hallmarks comes from cellular and molecular studies in rodent models. Yet these models cannot fully mimic how human astrocytes affect AD pathology as human and rodent astrocytes differ considerably

Deciphering OSM cytokine’s role in the breast tumor microenvironment Advanced breast cancer, particularly triple-negative (TN) breast cancer, presents a critical challenge due to its poor prognosis and the lack of effective targeted therapies. Addressing this urgent clinical need, our research focuses on the pro-inflammatory cytokine Oncostatin M (OSM) and its

Epigenetics, in modern times introduced by Conrad Hal Waddington (1942, British developmental biologist) opens up a new perspective on the regulation of our genes and the influence of environmental factors. If we understand these relationships, we can consciously influence the regulation of our genes. A new, far-reaching perspective that serves