X Congreso Internacional de Salud Digital
La Transformación Digital de la atención sanitaria es imprescindible para hacer frente al continuo cambio que experimenta el ecosistema de la salud. Es indiscutible que las tecnologías de la información y la comunicación permiten mejorar el autocuidado de la salud, la calidad de la asistencia y optimizar la eficiencia del
New 3D human biomodels to study the neurodegenerative diseases
Neurodegenerative diseases are chronic and multifactorial disesaes in which age, genetic, environmental factors, life style and diet represent the principal risk factors for neurodegeneration. Currently, the principal biomodels used to study the mechanisms and progression of neurodegeneration are animal models. However, more than 90% of the treatment in animal models
3D bioengineering models for breast cancer dormancy and bone metastasis
Early detection of disseminated cancer cells in metastatic niches such as the bone marrow is currently a highly complex challenge. Breast cancer cells that have abandoned their primary tumour tend to enter a dormant state once they reach these metastatic niches. In this context, there is an urgent need to
Navigating the Future and Overcoming Challenges to Unlock Open Science
Perfil de la ponente Eva Méndez es Profesora del Dpto. de Biblioteconomía y Documentación de la Universidad Carlos III de Madrid, donde ha sido además Vicerrectora Adjunta de Política Científica, de Estrategia y Educación digital y de Infraestructuras. Es la directora del grupo de investigación OpenScienceLab donde se desarrollan distintos
Pathological ATAD3 variants and perturbed cholesterol metabolism in human and fly
Among the hundreds of nuclear-encoded components of mitochondria that have been linked to human disease, mutations in the ATAD3 gene cluster have emerged as one of the most frequent in recent years. The ATAD3 locus encodes three highly homologous mitochondrial transmembrane proteins that are members of the AAA+ protein family.
Deficient interaction between FKBP12 and ryanodine receptors (RyRs) underlies several neuromuscular, cardiac and neurodegenerative diseases, such as RyR-related myopathies, Alzheimer’s disease and Duchenne muscular dystrophy. This deficiency, which may be caused by nitro-oxidative stress and genetic mutations, results in leaky RyR channels and ultimately leads to dysregulation of calcium homeostasis, endoplasmic
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