Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that rapidly affects motor neurons in the brain and spinal cord. This disease, up to date, has no cure. In about 90% of cases the origin of the disease is unknown, but in 10% it is caused by Mendelian inherited genetic

When thinking about cell reprogramming strategies, it is important to know what mechanisms act at the molecular level within the cell during the natural differentiation of cells. To illustrate cell differentiation, in 1957 Conrad Waddington introduced the Waddington Landscape metaphor from experimental observations but without numerical measurements. Today, thanks to

Amyotrophic Lateral Sclerosis (ALS) is the most frequent Motor Neuron (MN) disease that leads to the degeneration of both upper and lower MNs, muscle atrophy and consequent progressive loss of voluntary movements. Whereas the etiopathogenesis of ALS is still uncertain, growing evidence guide toward non-cell autonomous mechanisms that trigger neuromuscular

Mayte Suarez-Farinas is currently a Professor at the Center for Biostatistics and The Department of Genetics and Genomics Science of the Icahn School of Medicine at Mount Sinai, New York. She received a master’s degree in mathematics from the University of Havana, Cuba, and in 2003, a Ph.D. degree in