METABOLISMO Y CANCER

Cholangiocarcinoma 2026: status quo, unmet needs and priorities..

Banales JM, Rodrigues PM, Affò S, Andersen JB, Aspichueta P, Boulter L, Bridgewater J, Calvisi DF, Cardenas A, Cardinale V, Carpino G, Coulouarn C, Dopazo C, Edeline J, Fabris L, Folseraas T, Forner A, Goeppert B, Heikenwalder M, Kendall TJ, Khan SA, Klümpen HJ, Koerkamp BG, Lamarca A, Lindsey S, Lleo A, Luedde T, Macias RIR, Morement H, Nault JC, Olaizola P, Perugorria MJ, Raggi C, Rimassa L, Saborowski A, Valle JW, Vithayathil M, Vogel A, Braconi C.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 23, 65-96 (2026)

DOI: 10.1038/s41575-025-01153-w

Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4-/- mice.

Di Giorgio, Cristina, Urbani, Ginevra, Massa, Carmen, Marchiano, Silvia, Biagioli, Michele, Bordoni, Martina, Lachi, Ginevra, Sensini, Benedetta, Del Sordo, Rachele, Paniconi, Francesca, Giannelli, Eleonora, Sette, Maria Rosaria, Cari, Luigi, Morretta, Elva, Monti, Maria Chiara, De Gregorio, Rosa, Sepe, Valentina, Zampella, Angela, Lapitz, Ainhoa, Milkiewicz, Piotr, Milkiewicz, Malgorzata, Banales, Jesus M., Distrutti, Eleonora, Fiorucci, Stefano.

Hepatology Communications, 9, 0-0 (2025)

DOI: 10.1097/HC9.0000000000000779

The Effect of Ursodeoxycholic Acid (UDCA) on Serum Expression of miR-34a and miR-506 in Patients with Chronic Cholestatic Liver Diseases.

Cielica, E, Laba, A, Milkiewicz, P, Kruk, B, Kempinska-Podhorodecka, A, Klos, P, Rodrigues, PM, Val, B, Perugorria, MJ, Banales, JM, Milkiewicz, M.

Cells, 14, 0-0 (2025)

DOI: 10.3390/cells14151137

Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries' framework for digital twin advancement.

Carpino, G, Overi, D, Macias, RIR, Cardinale, V, Izquierdo-Sanchez, L, Acedo, P, Rengo, M, Doukas, M, Kendall, TJ, Calderaro, J, Heij, LR, Reichel, K, Leone, S, Onori, P, Franceschini, B, Soldani, C, Di Tommaso, L, Rodrigues, PM, Augustin, J, Brustia, R, Torzilli, G, Martin-Izquierdo, M, Hernández-Bayo, JM, Bueno-Sacristan, D, Lanza, EZ, Garcia-Sampedro, A, Quaglia, A, Ardito, F, De Rose, AM, Giuliante, F, Damato, E, Panebianco, V, Koerkamp, BG, Pereira, SP, Grazi, GL, Alvaro, D, Lleo, A, Banales, JM, Gaudio, E.

HEPATOLOGY, 0-0 (2025)

DOI: 10.1097/HEP.0000000000001425

Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice.

Di Giorgio, C, Urbani, G, Marchiano, S, Biagioli, M, Bordoni, M, Bellini, R, Massa, C, Lachi, G, Cari, L, Morretta, E, Spinelli, L, Monti, MC, Sepe, V, Zampella, A, Distrutti, E, Banales, JM, Lapitz, A, Milkiewicz, P, Milkiewicz, M, Fiorucci, S.

LIVER INTERNATIONAL, 45, 0-0 (2025)

DOI: 10.1111/liv.16235

Mitochondrial dynamics and auto(mito)phagy are altered in experimental models of primary biliary cholangitis, contributing to disease pathogenesis.

Lasa-Elosegi, I, Izquierdo-Sánchez, L, Olaizola, P, Lapitz, A, Tena-Garitaonaindia, M, Iturbe-Rey, S, Val, B, Fernandez-Barrena, MG, Bujanda, L, Perugorria, MJ, Rodrigues, P, Banales, JM.

JOURNAL OF HEPATOLOGY, 82, 0-0 (2025)

New platinum derivatives selectively cause double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinomas..

Olaizola I, Odriozola-Gimeno M, Olaizola P, Caballero-Camino FJ, Pastor-Toyos N, Tena-Garitaonaindia M, Lapitz A, Val B, Guimaraes AR, Asensio M, Huici-Izagirre M, Rae C, de Sancho D, Lopez X, Rodrigues PM, Herraez E, Briz O, Izquierdo-Sanchez L, Eleta-Lopez A, Bittner AM, Martinez-Amesti A, Miranda T, Ilyas SI, Braconi C, Perugorria MJ, Bujanda L, Rivilla I, Marin JJG, Cossío FP, Banales JM.

JOURNAL OF HEPATOLOGY, 83, 0-0 (2025)

DOI: 10.1016/j.jhep.2025.04.034

E2F1-driven metabolic dysregulation is involved in hippo pathway-driven cholangiocarcinoma progression.

Alfaro-Jiménez, K, de Gauna, MR, Nieva-Zuluaga, A, Apodaka-Biguri, M, Olaizola, I, Markaide, E, Izquierdo-Sánchez, L, Rae, C, González-Romero, F, Gómez-Jauregui, P, Sainz-Ramirez, N, Santos, BG, Buque, X, Aurrekoetxea, I, Delgado, I, Fernández-Puertas, I, Iglesias, A, Rourke, CO, Rodrigues, PM, Andersen, J, Calvisi, D, Morton, J, Braconi, C, Zubiaga, A, Banales, JM, Aspichueta, P.

JOURNAL OF HEPATOLOGY, 82, 0-0 (2025)

Novel "3-in-1" blood metabolomic test for the early diagnosis risk stratification of primary sclerosing cholangitis and cholangiocarcinoma.

Lapitz, A, Echebarria, A, Martínez-Arranz, I, Milkiewicz, P, Carbone, M, Macias, R, Alonso, C, Montilla, A, Milkiewicz, M, Fowsiyo, A, Elgozair, M, Izquierdo-Sánchez, L, La Casta, A, Jimenez-Aguero, R, Perugorria, MJ, Cristoferi, L, Hov, JR, Schramm, C, Crespo, G, Arrese, M, Chahuan, J, Bustamante, J, Lamarca, A, Karlsen, TH, Dill, M, Balderramo, D, Bujanda, L, Roberts, L, Folseraas, T, Rodrigues, PM, Banales, JM.

JOURNAL OF HEPATOLOGY, 82, 0-0 (2025)

Selective targeting of class I histone deacetylases with new derivatives of ursodeoxycholic acid as a novel treatment strategy for bile duct cancer.

Caballero-Camino, FJ, de los Toyos, NP, Olaizola, I, Rivilla, I, Guimaraes, A, Rodrigues, PM, Bujanda, L, Coss o, FP, Banales, JM.

JOURNAL OF HEPATOLOGY, 82, 0-0 (2025)