We present the cost-effectiveness analysis and the economic impact of the initial phase of the COVID-19 vaccination rollout in the Basque Country, Spain. To calculate costs and QALYs for the total Basque population, dynamical modelling and real-world data analysis were combined. The COVID-19 infection outcomes (cases, hospitalizations, intensive care unit

Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors with dismal prognosis. During the last years, different studies have highlighted the key role of the immune system in the development of CCA. Although immune cells can carry out anti-tumor immune responses, they can also be influenced in the presence of

NUEVA FECHA Y HORA Neddylation is a post-translational protein modification that controls multiple biological processes by covalently conjugating Nedd8 to specific targets. Neddylation takes part in neurogenesis and neuron differentiation. However, little is known regarding its function in brain aging. First, we identified that Neddylation is increased in human and

For years, standard 2D cellular cultures and animal models have been used to understand muscle physiopathology and to develop novel treatments for muscle diseases. Despite the many discoveries regarding those models, a comparison with native human muscle suggests that major challenges remain in order to obtain a fully representative or

La degeneración lobar frontotemporal (DFT) es una demencia neurodegenerativa que se acompaña de alteraciones del comportamiento, lenguaje o personalidad. Mutaciones en el gen progranulina (GRN) son causa mayor de DFT autosómica dominante (DFT-GRN). Estas mutaciones conducen a la haploinsuficiencia de progranulina que se traduce en una disminución de los niveles