Inherited Retinal Dystrophies (IRDs), such as Stargardt’s disease (STGD), lack effective treatments. STGD is characterised by mutations in the ABCA4 gene, leading to lipofuscin accumulation, oxidative stress (OS) and Ca2+ dysregulation, ultimately causing photoreceptor death. This study evaluates the therapeutic potential of MP-004, a small molecule designed to modulate OS and maintain Ca2+ homeostasis through […]

Dormancy is a reversible growth-arrest state that allows cancer cells to survive hostile environments and later reactivate under favorable conditions. In breast cancer, metastatic cells can seed distant organs -often lung and bone- and recurrence may occur decades later. Bioengineered 3D in vitro models enable tuning biophysical and biochemical properties to better recapitulate physiological niches […]

DNA viruses depend on host machinery for transcription and DNA maintenance, making host-virus interactions critical for viral persistence mechanisms. In this work, we identified the Ku70/Ku80 heterodimer, key components of the non-homologous end joining DNA repair pathways, as restriction factors for HBV infection and other DNA viral models. Silencing Ku proteins increased viral mRNA, protein […]