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X-WR-CALNAME:Biogipuzkoa
X-ORIGINAL-URL:https://bio-gipuzkoa.eus
X-WR-CALDESC:Eventos para Biogipuzkoa
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260203T100000
DTEND;TZID=Europe/Madrid:20260203T110000
DTSTAMP:20260525T093242
CREATED:20260122T125859Z
LAST-MODIFIED:20260122T125859Z
UID:103402-1770112800-1770116400@bio-gipuzkoa.eus
SUMMARY:Unraveling aging and health trajectories through Big Data
DESCRIPTION:The global increase in life expectancy is leading to a growing population of old adults worldwide. In consequence\, disability and multimorbidity rates are also increasing\, which constitutes a challenge for the healthcare system. However\, the aging process presents high heterogeneity\, and understanding the underlying relationship between healthspan and lifespan is essential for identifying distinct patterns in human aging. Electronic Health Records (EHRs) offer a unique opportunity to study aging dynamically\, but their longitudinal complexity remains underexploited. In this work\, we used machine learning techniques applied to EHR data from the Basque Country old individuals to explore aging trajectories. We identified sex-specific disease trajectories and their relationship with longevity\, highlighting the heterogeneous and individual nature of aging. We also examined centenarians as a model of successful aging and confirmed that they fit the compression of morbidity theory\, showing resilience against major age-associated conditions such as cancer\, neurodegenerative and cardiovascular diseases\, and COVID-19. Using a multivariate survival approach\, we derived a Resilience Index that quantifies individual aging trajectories over time and reveals distinct aging patterns in men and women. Overall\, our work provides an integrative\, data-driven framework to study human aging and disease.
URL:https://bio-gipuzkoa.eus/agenda/unraveling-aging-and-health-trajectories-through-big-data/
LOCATION:Salón de Grados de la Facultad de Enfermería
CATEGORIES:Agenda,Formación,Tesis Doctorales
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/01/SARA-CRUCES.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260220T133000
DTEND;TZID=Europe/Madrid:20260220T143000
DTSTAMP:20260525T093242
CREATED:20260216T122415Z
LAST-MODIFIED:20260216T122415Z
UID:104313-1771594200-1771597800@bio-gipuzkoa.eus
SUMMARY:MATRIXinCANCER: bridging bioengineered cancer models with the clinic / La propagación de TDP-43 en la ELA y DFT: nuevas perspectivas a partir de modelos de Drosophila melanogaster
DESCRIPTION:Dormancy is a reversible growth-arrest state that allows cancer cells to survive hostile environments and later reactivate under favorable conditions. In breast cancer\, metastatic cells can seed distant organs -often lung and bone- and recurrence may occur decades later. Bioengineered 3D in vitro models enable tuning biophysical and biochemical properties to better recapitulate physiological niches such as the tumor microenvironment (TME). Using hydrogel-based 3D cultures\, our group studies dormancy-supportive and metastatic microenvironments in breast cancer. Incorporating patient-derived cancer cells increases the translational relevance of these models. In MATRIXinCANCER\, in partnership with the Basque Biobank\, we have established workflows across four hospitals to collect breast-cancer–related patient samples to study the TME and develop more complex\, clinically relevant models. By integrating 2D and 3D cultures with TME characterization -through advanced imaging\, immune profiling and other approaches-\, our final goal is to build platforms for personalized drug testing. \n\nTBD
URL:https://bio-gipuzkoa.eus/agenda/matrixincancer-bridging-bioengineered-cancer-models-with-the-clinic-la-propagacion-de-tdp-43-en-la-ela-y-dft-nuevas-perspectivas-a-partir-de-modelos-de-drosophila-melanogaster/
LOCATION:Salón de Actos\, IIS Biogipuzkoa\, Paseo Dr. Begiristain\, s/n\, SAN SEBASTIÁN\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formación,Seminarios
ATTACH;FMTTYPE=image/png:https://bio-gipuzkoa.eus/wp-content/uploads/2026/02/2002.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260225T130000
DTEND;TZID=Europe/Madrid:20260225T133000
DTSTAMP:20260525T093242
CREATED:20260219T104112Z
LAST-MODIFIED:20260219T104112Z
UID:104399-1772024400-1772026200@bio-gipuzkoa.eus
SUMMARY:TRABAJAR Y CONVIVIR EN BIOGIPUZKOA
DESCRIPTION:Cuando se llega a un nuevo lugar de trabajo\, la gente se puede sentir algo perdida. O cuando lleva trabajando un tiempo\, tal vez no recuerde cosas o no conozca las nuevas. Así\, y siguiendo las acciones enmarcadas en la estrategia de excelencia en gestión de recursos humanos HRS4R\, todos los meses seguiremos dando la bienvenida a las nuevas personas incorporadas al equipo de Biogipuzkoa y recordaremos las claves que son necesarias conocer al poner los pies en nuestro Instituto.
URL:https://bio-gipuzkoa.eus/agenda/trabajar-y-convivir-en-biogipuzkoa/
LOCATION:Aula de Formación\, Biogipuzkoa
CATEGORIES:Agenda,Cursos/ Talleres,Formación
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2025/09/AMAIA-PEDRUZO-3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260227T133000
DTEND;TZID=Europe/Madrid:20260227T143000
DTSTAMP:20260525T093242
CREATED:20260219T103444Z
LAST-MODIFIED:20260219T103444Z
UID:104394-1772199000-1772202600@bio-gipuzkoa.eus
SUMMARY:Cellular Control of Extrachromosomal DNA: lessons from Ku heterodimer and the hepatitis B virus.
DESCRIPTION:DNA viruses depend on host machinery for transcription and DNA maintenance\, making host-virus interactions critical for viral persistence mechanisms. In this work\, we identified the Ku70/Ku80 heterodimer\, key components of the non-homologous end joining DNA repair pathways\, as restriction factors for HBV infection and other DNA viral models. Silencing Ku proteins increased viral mRNA\, protein levels and the amount of episomal genomes\, revealing their negative role in the regulation of viral DNA homeostasis. Transcriptomic analyses showed that Ku70 depletion alters the expression of genes involved in nucleosome assembly and cccDNA regulation. These findings deepen our understanding on host factors that are determinant for viral replication and support the development of therapeutic strategies targeting HBV persistence or biotechnological improvement of other episomal viral genomes stability as in the case of recombinant adeno-associated vectors. Additionally\, they provide new insights into the cellular mechanisms that could be involved into the regulation of extrachromosomal DNA.
URL:https://bio-gipuzkoa.eus/agenda/cellular-control-of-extrachromosomal-dna-lessons-from-ku-heterodimer-and-the-hepatitis-b-virus/
LOCATION:Salón de Actos\, IIS Biogipuzkoa\, Paseo Dr. Begiristain\, s/n\, SAN SEBASTIÁN\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formación,Seminarios
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/02/Enara-San-Sebastian.jpg
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