Lectura de Tesis Doctoral / Tesiaren irakurketa: “Delivery of microRNAs as a remyelination strategy in Multiple Sclerosis”

Doktoregaia / Doctorando:
Iñaki Osorio Querejeta. Esklerosi Anizkoitzaren Taldea, Biodonostia OII / Grupo de Esclerosis Múltiple, IIS Biodonostia.
Tesi Zuzendariak / Directores de Tesis: 
David Otaegui Bichot.
Maider Muñoz Culla. 
Data / Fecha: 2019ko urtarrilak 18, ostirala / Viernes 18 de enero de 2019.
Ordua / Hora: 11:30
Lekua / Lugar:
Erizaintza Eskolako Gradu Aretoa / Salón de Grados de la Escuela de Enfermería. Donostia.

Laburpena / Resumen:
Multiple sclerosis is a central nervous system disease for which no remyelination therapy is nowadays available and alternative strategies are being proposed as myelin regeneration inductors. In this sense, the use of microRNAs, and more concretely miR-219a-5p has been shown promising results. However, the delivery of microRNAs to the central nervous system is still a tricky question.

In this work the role that miR-219a-5p plays in remyelination has been reinforce by using oligodendrocyte precursor cell primary culture, cerebellar organotypic model and experimental autoimmune encephalomyelitis mice model. In addition, the ability of Liposomes Nanoparticles and Exosomes as pro-remyelinating microRNA delivery systems has been addressed in the same models concluding that Exosomes is the most effective delivery system.