MITOCHONDRIA, HEALTH & LONGEVITY

Aspartame decreases fat deposits in mice at a cost of mild cardiac hypertrophy and reduced cognitive performance..

Aiestaran-Zelaia I, Sánchez-Guisado MJ, Beraza M, López-Arandia L, Plaza-García S, Fernández-Folgueral I, Molina-Iracheta A, Holt IJ, Ruiz-Cabello J.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 194, 118891-118891 (2026)

DOI: 10.1016/j.biopha.2025.118891

Characterising PMP22-Proximal Partners in a Schwann Cell Model of Charcot-Marie-Tooth Disease Type1A..

Holt I, Emery N, Gates MA, Brown SJ, Shirran SL, Fuller HR.

Biology-Basel, 14, 0-0 (2025)

DOI: 10.3390/biology14111552

Metabolic Malfunction Mars Muscle Mitochondria..

Primiano G, Holt I.

NEUROLOGY-GENETICS, 10, 200126-200126 (2024)

DOI: 10.1212/NXG.0000000000200126

Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis.

Zufiría M, Pikatza-Menoio O, Garciandia-Arcelus M, Bengoetxea X, Jiménez A, Elicegui A, Levchuk M, Arnold-García O, Ondaro J, Iruzubieta P, Rodríguez-Gómez L, Fernández-Pelayo U, Muñoz-Oreja M, Aiastui A, García-Verdugo JM, Herranz-Pérez V, Zulaica M, Poza JJ, Ruiz-Onandi R, Fernández-Torrón R, Espinal JB, Bonilla M, Lersundi A, Fernández-Eulate G, Riancho J, Vallejo-Illarramendi A, Holt IJ, Sáenz A, Malfatti E, Duguez S, Blázquez L, López de Munain A, Gerenu G, Gil-Bea F, Alonso-Martín S.

ACTA NEUROPATHOLOGICA, 148, 43-43 (2024)

DOI: 10.1007/s00401-024-02794-y

Mitochondrial DNA competition: starving out the mutant genome..

Spinazzola A, Perez-Rodriguez D, Ježek J, Holt IJ.

TRENDS IN PHARMACOLOGICAL SCIENCES, 45, 225-242 (2024)

DOI: 10.1016/j.tips.2024.01.011

Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation..

Muñoz-Oreja M, Sandoval A, Bruland O, Perez-Rodriguez D, Fernandez-Pelayo U, de Arbina AL, Villar-Fernandez M, Hernández-Eguiazu H, Hernández I, Park Y, Goicoechea L, Pascual-Frías N, Garcia-Ruiz C, Fernandez-Checa J, Martí-Carrera I, Gil-Bea FJ, Hasan MT, Gegg ME, Bredrup C, Knappskog PM, Gereñu-Lopetegui G, Varhaug KN, Bindoff LA, Spinazzola A, Yoon WH, Holt IJ.

BRAIN, 147, 1899-1913 (2024)

DOI: 10.1093/brain/awae018

R-Loops and Mitochondrial DNA Metabolism..

Holt IJ.

Methods in molecular biology (Clifton, N.J.), 2528, 173-202 (2022)

DOI: 10.1007/978-1-0716-2477-7_12

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart.

Aiestaran-Zelaia I, Sánchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ruíz-Cabello J, Holt IJ.

SCIENTIFIC REPORTS, 12, 6890-6890 (2022)

DOI: 10.1038/s41598-022-10168-1

Defects of Nutrient Signaling and Autophagy in Neurodegeneration.

Ondaro J, Hernandez-Eguiazu H, Garciandia-Arcelus M, Loera-Valencia R, Rodriguez-Gómez L, Jiménez-Zúñiga A, Goikolea J, Rodriguez-Rodriguez P, Ruiz-Martinez J, Moreno F, Lopez de Munain A, Holt IJ, Gil-Bea FJ, GereÑu G.

Frontiers in Cell and Developmental Biology, 10, 836196-836196 (2022)

DOI: 10.3389/fcell.2022.836196

2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA.

Pantic B, Ives D, Mennuni M, Perez-Rodriguez D, Fernandez-Pelayo U, Lopez de Arbina A, Muñoz-Oreja M, Villar-Fernandez M, Dang TJ, Vergani L, Johnston IG, Pitceathly RDS, McFarland R, Hanna MG, Taylor RW, Holt IJ, Spinazzola A.

NATURE COMMUNICATIONS, 12, 6997-6997 (2021)

DOI: 10.1038/s41467-021-26829-0