Chronic liver diseases represent an escalating global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as a key driver of hepatocarcinogenesis. This seminar highlights the critical role of RIPK3, a central effector of necroptosis—a regulated, pro-inflammatory form of cell death—in liver disease progression. In MASLD, RIPK3 promotes hepatic

Our group and others have demonstrated that SOX9, a developmental transcription factor that is a master regulator controlling super-enhancer dynamics in stem cell plasticity, exerts a relevant pro-oncogenic role in multiple tumour types by regulating cancer stem cell (CSC) activity. Thus, different genes highly correlated with SOX9 in tumor samples

Environmental noise is a ubiquitous form of urban exposure and is considered a major environmental risk factor for public health. However, children are often underrepresented in research, and there is limited evidence on its effects among this subpopulation. To understand the impact of environmental noise on health, it is essential

Randomized clinical trials (RCTs) have long been the gold standard for establishing causal relationships in medicine, ensuring that treatments are evaluated with minimal bias. However, despite their rigor, RCTs face limitations in uncovering personalized treatment effects.  Artificial intelligence (AI) presents an exciting opportunity to enhance RCTs, offering advanced data-driven insights

En un 20% de los ictus isquémicos no se identifica la etiología y esto limita la aplicación de tratamientos específicos que han demostrado la reducción de recurrencias en prevención secundaria. Con el objetivo de aumentar las tasas de detección de fuente cardioembólica se implementó, con la colaboración con Cardiología,  un