Mechanism and treatment of RyR1-related skeletal muscle diseases
Type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum and plays an important role in excitation-contraction coupling. Genetic mutations in RyR1 cause various skeletal muscle diseases including malignant hyperthermia (MH) and central core disease. Since the main underlying mechanism of MH is overactive Ca2+-induced Ca2+
Development of Carbon Nanotubes-based Hydrogels for Nerve Tissue Regeneration
Nerve trauma often results in severe sensory and motor function loss due to axonal damage and demyelination. Current strategies aim to prevent neuromas formation and support guided nerve regeneration. Hydrogels, owing to their biomimetic properties, offer a promising platform for such applications. The thesis introduces three novel hydrogel types: PVA/CNT
Dr Bock’s research applies bioengineering strategies to study the bone organ and tumours in this microenvironment with the ultimate goal of identifying new mechanisms that may ultimately help to understand, prevent and treat disease. The specific focus is to develop and use biomimetic 3D tailorable tissue model systems for in
Inmunoterapia del cáncer basada en células NK
La inmunoterapia del cáncer utiliza el sistema inmunitario para eliminar células tumorales, y las células NK (natural killer) desempeñan un papel clave en este proceso. Estas células del sistema inmunitario innato pueden reconocer y destruir células cancerosas sin necesidad de sensibilización previa. Actualmente, se están realizando ensayos clínicos que emplean
Neoadjuvant endocrine therapy (NET) in oestrogen receptor-positive (ER+) / HER2-negative (HER2-) breast cancer (BC) allows real-time evaluation of treatment sensitivity and offers the opportunity of personalised BC therapy. However, the lack of reproducible biomarkers to assess response and long-term prognosis after NET is a significant barrier to increase its indications.
3D neuronal monitoring platforms for electrochemical sensing of neurotransmitters in vitro
Neurological diseases and mental disorders pose a major challenge due to their high prevalence and progressive neuronal degeneration, which often disrupts neurotransmitter release. Among the most critical neurotransmitters are glutamate and dopamine, both deeply involved in key neurophysiological processes and strongly associated with disorders like Parkinson’s, Alzheimer’s, and epilepsy. To
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