BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Biogipuzkoa - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Biogipuzkoa
X-ORIGINAL-URL:https://bio-gipuzkoa.eus/en/
X-WR-CALDESC:Events for Biogipuzkoa
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260608T103000
DTEND;TZID=Europe/Madrid:20260608T113000
DTSTAMP:20260608T131554
CREATED:20260603T080952Z
LAST-MODIFIED:20260603T080952Z
UID:106243-1780914600-1780918200@bio-gipuzkoa.eus
SUMMARY:Improving Early Detection and Treatment of Hepatobiliary Cancers
DESCRIPTION:Dr. Lewis R. Roberts is the Peter and Frances Georgeson Professor in Gastroenterology Cancer Research and Distinguished Investigator at the Mayo Clinic\, where he is Co-Principal Investigator of the Mayo Clinic Specialized Program of Research Excellence in Hepatobiliary Cancers and the International Consortium for the Genetics of Biliary Tract Cancers. Dr. Roberts’ research focuses on development of hepatobiliary cancers; biomarkers for early diagnosis of liver\, biliary and pancreas cancers; and prevention\, diagnosis\, and treatment of liver and biliary cancers. Dr. Roberts serves as President of the Africa Institute for Liver and Digestive Diseases Foundation; and as a Board member of the Hepatitis B Foundation and the Ashesi University Foundation. He is a founding member of the Africa HepatoPancreatoBiliary Cancer Consortium.
URL:https://bio-gipuzkoa.eus/en/agenda/improving-early-detection-and-treatment-of-hepatobiliary-cancers/
LOCATION:Salón de Actos\, IIS Biogipuzkoa\, Paseo Dr. Begiristain\, s/n\, SAN SEBASTIÁN\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formation,Seminars
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/06/LRR-050626-Headshot.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260612T120000
DTEND;TZID=Europe/Madrid:20260612T133000
DTSTAMP:20260608T131554
CREATED:20260605T090427Z
LAST-MODIFIED:20260608T094040Z
UID:106291-1781265600-1781271000@bio-gipuzkoa.eus
SUMMARY:Mecanismos y estrategias terapéuticas para restablecer la homeostasis proteica en la ELA/DFT: del estrés celular a la propagación patológica de TDP-43
DESCRIPTION:La Esclerosis Lateral Amiotrófica (ELA) es una enfermedad neurodegenerativa letal caracterizada por la degeneración progresiva de las motoneuronas y por una compleja interacción de factores genéticos\, ambientales y celulares. Esta complejidad se manifiesta en los pacientes con una sintomatología y desarrollo heterogéneo con una supervivencia entre los 2 y 5 años desde el inicio de los síntomas. A pesar de esta heterogeneidad\, la enfermedad presenta un marcador histopatológico unificador: la presencia de inclusiones citoplasmáticas de TDP-43. Sin embargo\, aunque se han identificado numerosos mecanismos relacionados con el desarrollo de la enfermedad\, todas las estrategias terapéuticas testadas hasta el momento han fracasado. Por lo tanto\, identificar nuevos mecanismos patológicos y desarrollar nuevas estrategias multidiana\, en forma de nuevas entidades químicas (NCEs) o estrategias de reposicionamiento de fármacos debe ser prioritaria. Con este objetivo\, la presente tesis doctoral industrial propone una teoría integrativa que vincula un mecanismo patológico emergente con un nuevo proceso relacionado con la propagación de la patología. Hemos diseñado\, sintetizado y testado en modelos celulares humanos y modelos de Drosophila melanogaster de enfermedad una familia de NCEs\, además de testar la eficacia de un fármaco de reposicionamiento para atacar el nuevo mecanismo patológico identificado.
URL:https://bio-gipuzkoa.eus/en/agenda/mecanismos-y-estrategias-terapeuticas-para-restablecer-la-homeostasis-proteica-en-la-ela-dft-del-estres-celular-a-la-propagacion-patologica-de-tdp-43/
LOCATION:Grados de la Facultad de Medicina y Enfermería en San Sebastián.
CATEGORIES:Agenda,Doctoral theses,Formation
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/06/ANGELA-SANCHEZ.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260612T133000
DTEND;TZID=Europe/Madrid:20260612T143000
DTSTAMP:20260608T131554
CREATED:20260608T064846Z
LAST-MODIFIED:20260608T064846Z
UID:106310-1781271000-1781274600@bio-gipuzkoa.eus
SUMMARY:Human neural rosettes secrete extracellular vesicles that promote neuronal maturation via neuroglial cargoes / Establishment of airway epithelium organoids for lung disease modelling
DESCRIPTION:Extracellular vesicles (EVs) are nanovesicles involved in intercellular communication in the central nervous system (CNS). While stem cell-derived EVs have shown promising therapeutic potential in CNS disorders\, their uptake mechanisms and biological effects remain poorly understood. \nThis project evaluates the regenerative potential of EVs secreted by human induced pluripotent stem cell (hiPSC)-derived neural rosettes (hNR-EVs)\, cellular structures enriched in neural stem cells. We found that hNR-EVs promote neurite outgrowth and neuronal maturation in both human and murine neurons. \nBy integrating omics\, single-EV analyses\, and functional inhibition assays\, we identified the major proteolipid protein (PLP) as a key neuroglial cargo mediating these trophic effects. Although PLP is traditionally recognized as the principal structural protein of CNS myelin\, it is also expressed in neurons\, where its function remains poorly characterized. Our findings suggest a previously unrecognized role for PLP in EV-mediated communication within the CNS. \n\nRespiratory diseases represent a complex challenge in disease modelling due to the multiple factors involved\, the cellular heterogeneity of the lungs\, and the diverse threats they face. While in vitro lung models can replicate some of these conditions\, lung organoids are uniquely positioned to retain organ-like capabilities and mimic relevant physiological functions of the airways. Consequently\, they are ideally suited as screening platforms for disease research and as personalized medicine tools to predict treatment responses and facilitate clinical decision-making. \nDiseases such as idiopathic pulmonary fibrosis (IPF) require models that capture the complexity of the entire lung\, particularly the crosstalk between the different cell types that act as a driver of the disease. To address this\, our group has established an efficient and reproducible protocol for the in vitro generation of mature mouse airway organoids. Moreover\, we are focused in modeling IPF with them. By mimicking the cellular heterogeneity of respiratory tissue\, these organoids could help to develop a robust platform for drug screening and novel treatments
URL:https://bio-gipuzkoa.eus/en/agenda/human-neural-rosettes-secrete-extracellular-vesicles-that-promote-neuronal-maturation-via-neuroglial-cargoes-establishment-of-airway-epithelium-organoids-for-lung-disease-modelling/
LOCATION:Salón de Actos\, IIS Biogipuzkoa\, Paseo Dr. Begiristain\, s/n\, SAN SEBASTIÁN\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formation,Seminars
ATTACH;FMTTYPE=image/png:https://bio-gipuzkoa.eus/wp-content/uploads/2026/06/1206.png
END:VEVENT
END:VCALENDAR