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DTSTART;TZID=Europe/Madrid:20260604T120000
DTEND;TZID=Europe/Madrid:20260604T130000
DTSTAMP:20260525T073827
CREATED:20260522T113109Z
LAST-MODIFIED:20260522T113109Z
UID:106090-1780574400-1780578000@bio-gipuzkoa.eus
SUMMARY:Dissecting the molecular origins of biliary tract cancer
DESCRIPTION:Why patients with chronic tissue inflammation and fibrosis often develop ductular cancers in their liver\, gallbladder and pancreas is not understood. While screening has improved early detection and subsequent survival for some patients with cancer\, those with chronic disease often present with established malignancies for which treatment options are limited. In the liver and pancreas\, chronic tissue damage results in inflammation\, repair and tissue scarring\, where a collagen-rich matrix makes tissues stiffer. Stiffness is associated with cancer cell proliferation in established tumours; though how chronic inflammation and scarring makes tissues more susceptible to tumour initiation remains unclear. Across organs\, genetic mutations are often insufficient to drive cancer formation. As such\, the Liver Growth and Cancer lab are interested in identifying additional tumour-initiating factors that enable mutant cells to form neoplasms. Specifically\, we address how\, during organ repair\, changing fibroinflammatory landscapes regulate ductular disease and ask how cancer cells hijack this regenerative response to promote tumour initiation. Leveraging this information\, we dissect how ductular pre-cursor lesions begin in high-risk patients. Understanding the origins of cancer in chronic disease will enable us to detect cancer earlier and by specifically uncoupling tumour-initiating cells from their microenvironment\, we propose we can prevent cancer progression in those high-risk patients with chronic inflammatory disease.
URL:https://bio-gipuzkoa.eus/agenda/dissecting-the-molecular-origins-of-biliary-tract-cancer/
LOCATION:Salón de Actos\, IIS Biogipuzkoa\, Paseo Dr. Begiristain\, s/n\, SAN SEBASTIÁN\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formación,Seminarios
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/05/DSC_7159b.jpg
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DTSTART;TZID=Europe/Madrid:20260608T110000
DTEND;TZID=Europe/Madrid:20260608T123000
DTSTAMP:20260525T073827
CREATED:20260515T105525Z
LAST-MODIFIED:20260515T105525Z
UID:106013-1780916400-1780921800@bio-gipuzkoa.eus
SUMMARY:Estrategias de detección y prevención del deterioro cognitivo
DESCRIPTION:Esta tesis doctoral se centra en la prevención del deterioro cognitivo y la demencia mediante un enfoque poblacional basado en factores de riesgo modificables. En primer lugar\, se evalúa la utilidad de los test cognitivos breves como herramientas clínicas en atención primaria para mejorar la atención a las personas con quejas cognitivas y optimizar la toma de decisiones en los circuitos asistenciales. En segundo lugar\, se analiza la viabilidad\, la adherencia y los efectos cognitivos preliminares de una intervención multidominio sobre el estilo de vida de adultos mayores con mayor riesgo de demencia\, adaptada al contexto sociocultural del sur de Europa\, demostrando su factibilidad en un entorno comunitario. Finalmente\, se describe el diseño y el proceso de reclutamiento de un ensayo clínico poblacional a gran escala\, orientado a evaluar la eficacia\, el impacto clínico y la coste-efectividad de una intervención multidominio en la prevención del deterioro cognitivo\, con el objetivo de generar evidencia transferible a la práctica clínica y a las políticas de salud pública.
URL:https://bio-gipuzkoa.eus/agenda/estrategias-de-deteccion-y-prevencion-del-deterioro-cognitivo/
LOCATION:Salón de actos Hospital Universitario Donostia
CATEGORIES:Agenda,Formación,Tesis Doctorales
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/05/mikel-tainta.jpg
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