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DTSTART;TZID=Europe/Madrid:20260116T133000
DTEND;TZID=Europe/Madrid:20260116T143000
DTSTAMP:20260525T102309
CREATED:20260109T131049Z
LAST-MODIFIED:20260109T131134Z
UID:103228-1768570200-1768573800@bio-gipuzkoa.eus
SUMMARY:How the start-up of an energy recovery plant influences PCDD/F and dl-PCB air levels in northern spain / Restoring Mitochondrial Manganese Homeostasis to Correct ER–Mitochondria Dysfunction in Neurodegenerative Diseases
DESCRIPTION:Waste-to-energy facilities are a key component of circular economy strategies\, but their potential impact on air quality remains a public concern. This study evaluated whether the start-up of an energy recovery plant in northern Spain affected airborne levels of dioxins\, furans (PCDD/Fs)\, and dioxin-like PCBs (dl-PCBs). Air samples were collected from 2017 to 2023 in two urban–industrial areas\, one potentially affected by the plant and a control area. Concentrations before and after plant commissioning were compared using a before–after control–impact approach. Although pollutant levels were initially higher in the impact area\, both sites showed a significant decline over time\, with concentrations converging by the end of the study period. No statistically significant changes attributable to the plant start-up were observed. Similar congener profiles before and after commissioning suggest that regional industrial activities\, rather than the energy recovery plant\, are the main drivers of atmospheric PCDD/F and dl-PCB levels. \n\n  \nMitochondrial function is reliant on interactions with other cell compartments\, particularly the endoplasmic reticulum\, via endoplasmic reticulum-mitochondrial contact sites (ERMCS). In this seminar\, I will unravel how the ER influences mitochondrial DNA (mtDNA) replication\, an essential process for cellular energy production and survival. \nThe research\, conducted using both fibroblast and neuronal cell models\, demonstrated a direct correlation between ERMCS abundance and mtDNA synthesis. Besides\, I found that disrupting ERMCS via gene silencing (RTN4\, ERLIN2\, GRP75) significantly represses mtDNA replication. In addition\, I identified manganese as a key ER-mitochondria signalling molecule that stimulates mtDNA replication and proposed a model which involves mitochondrial calcium uniporter transport and regulation. This work contributes significantly to the understanding of ER-mitochondria communication mechanisms\, and suggests potential therapeutic avenues for stimulating mtDNA replication in cases of neurodegenerative disorders with ERMCS dysfunction.
URL:https://bio-gipuzkoa.eus/agenda/how-the-start-up-of-an-energy-recovery-plant-influences-pcdd-f-and-dl-pcb-air-levels-in-northern-spain-restoring-mitochondrial-manganese-homeostasis-to-correct-er-mitochondria-dysfunction-in/
LOCATION:Biogipuzkoa\, Pº Dr. Beguiristain s/n\, Donostia\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formación,Seminarios
ATTACH;FMTTYPE=image/png:https://bio-gipuzkoa.eus/wp-content/uploads/2026/01/1601.png
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260123T110000
DTEND;TZID=Europe/Madrid:20260123T120000
DTSTAMP:20260525T102309
CREATED:20260113T095521Z
LAST-MODIFIED:20260113T095521Z
UID:103281-1769166000-1769169600@bio-gipuzkoa.eus
SUMMARY:Synthetic Tabular Data for Privacy-Preserving Data Sharing and Analysis in Health Research: Evaluation Frameworks and Infrastructure Integration.
DESCRIPTION:The increasing use of artificial intelligence in healthcare has created a strong need for large amounts of high-quality data\, while privacy and ethical regulations continue to limit data access. Synthetic data offers a practical solution by allowing data to be shared and analysed without exposing information about real individuals. However\, its adoption in healthcare has been slow due to uncertainty about how to assess data quality and privacy\, as well as limited integration into real-world data systems. \nThis thesis explores how synthetic tabular data can be generated\, evaluated\, and safely used in healthcare settings. It shows that synthetic data can closely resemble real-world data\, remain useful for analysis\, and significantly reduce privacy risks at the same time. The work also demonstrates how synthetic data can be incorporated into secure data-sharing infrastructures\, supporting responsible data use while protecting sensitive information. Overall\, the results highlight synthetic data as a valuable tool for enabling privacy-preserving analytics in healthcare\, while pointing to the need for further development to ensure robust and widespread real-world adoption.
URL:https://bio-gipuzkoa.eus/agenda/synthetic-tabular-data-for-privacy-preserving-data-sharing-and-analysis-in-health-research-evaluation-frameworks-and-infrastructure-integration/
LOCATION:Salón Ada Lovelace (Facultad de Informática)
CATEGORIES:Agenda,Formación,Tesis Doctorales
ATTACH;FMTTYPE=image/jpeg:https://bio-gipuzkoa.eus/wp-content/uploads/2026/01/MIKEL-HERNANDEZ-web.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20260130T133000
DTEND;TZID=Europe/Madrid:20260130T143000
DTSTAMP:20260525T102309
CREATED:20260122T131300Z
LAST-MODIFIED:20260122T131300Z
UID:103408-1769779800-1769783400@bio-gipuzkoa.eus
SUMMARY:Exploring the therapeutic potential of the MP-004 compound in Stargardt’s disease: insights from an in vivo model / Conductive 3D scaffolds for electroactive neuron and cardiomyocyte in vitro modelling
DESCRIPTION:Inherited Retinal Dystrophies (IRDs)\, such as Stargardt’s disease (STGD)\, lack effective treatments. STGD is characterised by mutations in the ABCA4 gene\, leading to lipofuscin accumulation\, oxidative stress (OS) and Ca2+ dysregulation\, ultimately causing photoreceptor death. \nThis study evaluates the therapeutic potential of MP-004\, a small molecule designed to modulate OS and maintain Ca2+ homeostasis through ocular instillation. Using an acute light-induced photo toxicity mice model (Abca4-/- Rdh8-/-) we demonstrate that MP-004 significantly preserves retinal function. Longitudinal ERGs showed that treated animals maintained significantly higher scotopic and photopic responses compared to controls for at least to 5 months (ongoing study). Furthermore\, the study revealed a notable sex-related difference: female mice exhibited lower baseline ERG amplitudes and greater sensitivity to phototoxicity compared to males. These findings support MP-004 as a promising\, non-invasive candidate for the functional protection of the retina in STGD and other IRDs. \n\nIn recent years scaffolds containing carbon nanotubes (CNTs) have emerged as promising conductive materials to interface with electroactive tissues due to their unique electrical and mechanical properties. The use of patterns\, especially hexagonal patterns\, has also been proven to improve 3D cell culture environment for in vitro modelling. We designed 3D printable hydrogels with and without CNTs in order to study the effect of both surface pattern and CNT incorporation on electroactive hiPSC-derived neuron and cardiomyocyte differentiation. We found that CNTs and surface topography greatly affects neuronal culture maturation\, by improving neuronal marker expression\, calcium transient amplitude and axonal network maturation\, while cardiomyocyte culture was mainly impacted by CNT presence independently of surface structure. In future experiments a more complex dual-conductive scaffold matrix and structure will be studied. Overall\, this study provided insights into the impact of surface structure and composition in electroactive cell differentiation and maturation.
URL:https://bio-gipuzkoa.eus/agenda/exploring-the-therapeutic-potential-of-the-mp-004-compound-in-stargardts-disease-insights-from-an-in-vivo-model-conductive-3d-scaffolds-for-electroactive-neuron-and-cardiomyocyte-in-vitro/
LOCATION:Biogipuzkoa\, Pº Dr. Beguiristain s/n\, Donostia\, Gipuzkoa\, 20014\, Spain
CATEGORIES:Agenda,Formación,Seminarios
ATTACH;FMTTYPE=image/png:https://bio-gipuzkoa.eus/wp-content/uploads/2026/01/3001.png
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